Familial Mediterranean Fever Overview

The inherited ailment characterized by recurrent bouts of fever, inflammation, and pain in the chest, muscles and joints is known as familial Mediterranean fever. This rare disorder can be diagnosed early in life however, first signs of recurrent attacks usually occurs in the later teenage years. This disease generally effects those people originating within Armenia, Turkey and other surrounding Mediterranean regions. That being said, it can still affect those of different nationalities. While severity ranges from patient to patient, these recurrent episodes can last anywhere between a few hours up to 3 days.

Treating FMF
Colchicine is the drug used to treat familial Mediterranean fever. It has been proven to be the most effective form of treatment, helping to dramatically reduce episodic attacks and further complications for the majority of FMF sufferers. Without this prescribed drug, amyloidosis, better known as the build of amyloid protein, can occur throughout the organs and tissues of the body, resulting in the potential for kidney failure. It is best for FMF patients to use colchicine under the discretion of their physicians approval.

Here are some other names individuals use for Familial Mediterranean Fever:

FMF
Periodic Peritonitis
MEF
Reimann Periodic Disease
Wolff Periodic Disease
Recurrent Polyserositis
Mediterranean Fever, Familial
Siegal-Cattan-Mamou Disease
Periodic Disease

The Gene Associated With Periodic Peritonitis
The MEFV gene helps regulate inflammation and produces the pyrin protein found in white blood cells. Mutations of this gene cause FMF by reducing the amount of protein pyrin produced, which interferes with the regulation of inflammation and signaling white blood cells to injury sites. Symptoms and attacks including muscle, joint, abdominal pain and fever are a result of prolonged inflammatory response.

FMF Inheritance
Both gene copies in cells will have mutations in order for someone to be diagnosed with familial Mediterranean fever. In other words, while both parents of a child obtaining an autosomal recessive condition carry a copy of the gene mutation without showing any symptoms of the condition, it is typically inherited in an autosomal recessive form. There are other cases where this condition can be inherited in various forms including an autosomal recessive inheritance and an autosomal dominant pattern.

A healthy body can fight off cancer cells and when the body can control or manage inflammation or is capable of resisting pathogens, diseases and cancers can be avoided. If you feel your suffering from inflammation, make sure to consult your nearest physician to learn more about your current condition.


Article Source: http://EzineArticles.com/7245306


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Stomach Cancer Signs and Symptoms - When to Seek Cancer Treatment?

Stomach cancer is associated with many signs and symptoms. Unfortunately, some of these symptoms don't effectively alert patients, who often pass them off as passing discomforts and minor health problems. This makes cancer very difficult to diagnose. Some of the common stomach cancer signs and symptoms include:

• Indigestion
• Stomach pain or discomfort
• Bloating
• Nausea
• Vomiting
• Loss of appetite
• Heartburn

These symptoms are linked to several other diseases, some of which are not as serious as cancer. Sometimes, the symptoms are also very mild and can even disappear for some time. Thus, it is easy to understand why some people fail to seek medical attention and only find out about their illness when the cancer has already progressed.

However, if a person misses these early symptoms, they are usually followed by more severe ones, such as:

• Bloody stools
• Sudden weight loss
• Fatigue
• Moderate to severe stomach pain

If the early symptoms are identified, however, they can be managed, and cancer specialists can help the patient deal with these more serious symptoms. In many cases where the cancer is diagnosed early, the pain and discomfort can be minimized. However, if a patient only seeks medical attention when the symptoms are already severe, he may have to suffer a lot of these more serious symptoms, leading to a lot of pain and discomfort. This will lower the quality of the patient's life and may render him unable to do even simple everyday activities.

If you go to a cancer specialist complaining of symptoms that suggest stomach cancer, your doctor will check you first for digestive problems. A gastroenterologist may be brought in to check your case. Cancer is usually avoided as a diagnosis until other possible problems have been ruled out or until actual evidence of the cancer can be found in tests. These tests will include blood testing and other laboratory tests including:

• Physical exam, to check for swelling, fluid, or other abnormalities in your abdomen
• Endoscopy, to check the esophagus and stomach with the use of a thin, lighted tube
• Biopsy, in which some tissue is removed from the stomach to check if cancer cells are present

Be prepared to answer questions regarding your personal health history. And since cancer is sometimes associated by genetic factors, you will also be asked about your family's health history.

As a patient, you will also be given time to ask your own questions, especially with regards to the tests you will be put under.

If stomach cancer is diagnosed, the next step is to determine the stage at which the cancer is. This is necessary in determining the best treatment plan for you. In stomach cancer, the process of staging will determine how deeply the tumor has invaded the stomach wall, whether the tumor has invaded the tissues nearby, and whether the cancer has spread from the stomach to other parts of the body. Then your cancer specialist will discuss the possible treatment options with you for your recovery and symptoms management.

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Facts About Metastatic Cancer

The process by which cancer spreads from its original location to another part of the body is called Metastasis. Cancerous cells found in a different organ of an individual can also be similar to the original manifestation in terms of some proteins and chromosomal variations. For instance, Colon cancer that spreads to the Lungs is actually the extended Colon cancer and not Lung cancer. Despite its propensity to spread to different parts of the body, cancer tends to spread to one site more often than others. If properly treated, Metastasis can be cured in some cases but sadly it is mostly fatal. The regimen that is available can only prolong life for months or maybe a year or two.

Common Metastasis sites for different cancer types are identifiable. They usually spread from the breast to the lungs and then to the liver and bones or from the colon to the liver, peritoneum and the lungs.

The various stages of Metastasis-
• Local invasion of cancer cells on normal nearby tissue
• Intravasation, where they enter nearby lymph or blood vessels
• Circulation through Lymphatic system and Bloodstream to other body parts
• Arrest and Extravasations of distant capillaries to move into surrounding tissues
• Proliferation of small tumors called Micrometastases
• Angiogenesis or stimulation of new blood vessels for continued tumor growth

All cancer cells cannot metastasize even if they succeed in reaching another location in the body. At times they can lie dormant and revitalize after years. Metastasis can be found out through X-rays, CT Scan or MRI.

Metastasis symptoms-
• Bone cancer is painful and often results in fractures.
• Lung Metastasis is characterized by shortness of breath.
• Liver Metastasis can lead to abdominal swelling or jaundice.
• An affected Brain can cause headaches, seizures and unsteadiness.
• Sometimes original Prostate cancer is itself detected after Bone Metastasis causes lower back pain.

Treatment for Metastatic Cancer-

Chemotherapy, Biological, Targeted or Hormonal therapy, Surgery and Radiation or a combination of these treatments is known to provide relief to patients. Treatment is provided after bringing into account a lot of considerations such as the type of primary cancer, size, number and location of metastatic tumors, patient's age, his general health and the types of illness he has had in the past. However, even after treatment is provided it is possible for a person to be diagnosed with cancer a second time. It can be a new primary cancer but most often it is Metastatic Cancer. In some cases it happens that primary cancer may not be identified even when the symptoms of Metastatic Cancer are evident. Even in such cases there is hope for effective treatment.


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7" Android 4.0 OS Cortex A8 5 Point Capacitive Touchscreen Tablet PC Google 3G WiFi MID

This product arrived one day before the expected delivery date. I was impressed that this item ships fully charged and ready to use right out of the box. I am still getting used to the ice cream sandwhich system because I currently use honeycomb on my android phone. I have noticed the battery life is kind of short on this item but that is to be expected with the price we paid for this item. This product is light and does not feel cheaply made. The wifi works great if I am using my home network or my phone as a hotspot. The system seems to respond well so far and plays flash videos very quickly. I am very happy with this product and I will be buying two more of these units for my children because I am sure once they touch it they will want it. I will update this review once I try the hdmi port and other features.

I just recv'd my new toy....7" Android 4.0 OS tablet and keyboard protector case. This little device is worth every penny....<$100 for the tablet itself and a for a few xtra bucks, a really decent keyboard which attaches to the small adaptor included with the tablet. I also purchased screen protectors and an xtra micro SD card. I recv'd all of these items on the same day, well before the anticipated delivery date. I didn't expect to get these before the holiday, but to my great pleasure, everything came Mon. 7/2/12. I've been hard-pressed to put it down! I did alooot of research re: tablets and I came back to Amazon.com. I've been an Amazon customer for some time and I can honestly say that I've never had a bad experience with Amazon. I've gotten all my orders delivered timely and efficiently, and always intact. As far as the tablet goes, it's very user friendly, nice and slim to handle. Fits nicely in the Android keyboard/protector. The only complaints I have are: the tablet does get hot from use and the touch screen can be a bit sensitive. I have a smart phone, so I am quite familiar w/ the Android OS. Great product for the money and great start to the world of tablet ownership, especially if you're on a budget.

This product arrived one day before the expected delivery date. I was impressed that this item ships fully charged and ready to use right out of the box. I am still getting used to the ice cream sandwhich system because I currently use honeycomb on my android phone. I have noticed the battery life is kind of short on this item but that is to be expected with the price we paid for this item. This product is light and does not feel cheaply made. The wifi works great if I am using my home network or my phone as a hotspot. The system seems to respond well so far and plays flash videos very quickly. I am very happy with this product and I will be buying two more of these units for my children because I am sure once they touch it they will want it. I will update this review once I try the hdmi port and other features.

I just recv'd my new toy....7" Android 4.0 OS tablet and keyboard protector case. This little device is worth every penny....<$100 for the tablet itself and a for a few xtra bucks, a really decent keyboard which attaches to the small adaptor included with the tablet. I also purchased screen protectors and an xtra micro SD card. I recv'd all of these items on the same day, well before the anticipated delivery date. I didn't expect to get these before the holiday, but to my great pleasure, everything came Mon. 7/2/12. I've been hard-pressed to put it down! I did alooot of research re: tablets and I came back to Amazon.com. I've been an Amazon customer for some time and I can honestly say that I've never had a bad experience with Amazon. I've gotten all my orders delivered timely and efficiently, and always intact. As far as the tablet goes, it's very user friendly, nice and slim to handle. Fits nicely in the Android keyboard/protector. The only complaints I have are: the tablet does get hot from use and the touch screen can be a bit sensitive. I have a smart phone, so I am quite familiar w/ the Android OS. Great product for the money and great start to the world of tablet ownership, especially if you're on a budget.

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Acer Aspire V3-571G-6602 15.6-Inch Laptop (Midnight Black)

This laptop is exactly what I wanted. A mid weight laptop with a core i5 processor and a dedicated graphics card to be able to run Guild Wars 2 when it releases in August. Most other laptops here on Amazon in this price range had the processor I was looking for but only had integrated graphics, which are not recommended for gaming. I really like the LED screen, it has a light gloss look to it but not too shiny. Great thin, sleek design. The glossy cover looks great when it is clean but is a fingerprint magnet. When I was looking over the product features I overlooked the Dolby speakers it had and was surprised at the quality when I put some music on YouTube. I mean, they don't get VERY loud but for a laptop the quality is fantastic. I plan to upgrade the 4gb of ram currently installed.

As for gaming, I ran a test on the System Requirements Lab website to get a picture on how this machine would run Guild Wars 2. It said that this PC would run GW2 as "Fast". I even ran a test on how it would run Mass Effect 3 and it exceeded both the minimum and recommended specifications. That being said I will update once GW2 releases on how well it runs the game and maybe Mass Effect 3 if I decide to buy it.

First and foremost, remove a star or even two if you're going to do any hardware modification such as HDD replacement, or even just reinstalling a fresh windows to remove bloatware. A fresh install of windows won't see much of the laptop hardware at all, and requires that you get all of the drivers from Acer's website then burn them to a disc. Please note that both the LAN and WLAN will not function, meaning that you must grab the drivers from another computer. To top it all off, acer's drivers are quite behind but are still required for your hardward to even see any updates for it; biggest being the Nvidia Optimus duo. Get the acer version drivers for both Intel HD and Nvidia, install, then get the latest versions of both from their respective websites and reinstall (the beta 304.79 is the only Nvidia driver that will install correctly under optimus and only after you update the Intel HD to it's own latest drivers). It goes past being a critical annoyance.

For the raw hardware, though, this is a decent deal. The specs are good enough to play modern games on at least mid (and more than likely high) due to the combination of the still-current GT 630M and the somewhat-low 1366x768 screen resolution. LoL and Dota2 load up just fine, as does Diablo 3. GW2 runs fine at mid, but that's the beta build.

As far as video performance goes, you CAN run the supercodec madVR at full settings with 1080p content, which is an accomplishment at this price. However, the laptop does not play blu-rays without an external player, so good luck using it for that.

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